| Name | MK-0557 |
| Description | MK-0557 is a selective and orally available antagonist of the neuropeptide Y5 receptor (Ki: 1.6 nM). |
| In vitro | MK-0557 has a Ki=1.3 nM at the human NPY5R, with similar affinities at rhesus, mouse, and rat NPY5R. MK-0557 has no significant binding to the human NPY1R, NPY2R, NPY4R, or mouse NPY6R at concentrations of 10 μM [2]. |
| In vivo | MK-0557 counteracts the NPY5R-selective agonist's influence on body-weight gain and hyperphagia in C57BL/6J mice, also markedly reducing body-weight gain in diet-induced obese (DIO) mice. A 40% reduction in body-weight gain is achieved by day 35 in lean mice shifted from regular chow to a medium high-fat diet (4.2 kcal/g), following treatment with MK-0557 at a dosage of 30 mg/kg PO QD[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 2 mg/mL (4.92 mM), Sonication is recommended. DMSO : 25 mg/mL (61.51 mM), Sonication is recommended.
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| Keywords | Y5 receptor | NPY receptor | NeuropeptideYReceptor | Neuropeptide Y Receptor | neuropeptide Y (NPY) Y5 receptor | neuropeptide Y (NPY) receptor | MK-0557 | MK0557 | MK 0557 | Inhibitor | inhibit |
| Inhibitors Related | [Leu31,Pro34]-Neuropeptide Y (porcine) | Lu AA33810 | (S)-VU0637120 | Galanin (1-16), mouse, porcine, rat | SF 11 | GW438014A | M617 acetate | JNJ-31020028 | Galantide acetate | DF-1012 FA | M871 acetate | Pancreatic Polypeptide (human) acetate |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Obesity Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | NO PAINS Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | GPCR Compound Library | Anti-Cancer Drug Library |