| Name | MnTBAP chloride |
| Description | MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory effects through upregulation of BMPR-II and inhibition of NFκB signaling. mnTBAP chloride is a manganese porphyrin complex with antioxidant properties and has potential for use in the study of fibrotic responses in chronic kidney diseases (CKDs). |
| In vitro | Due to its superoxide dismutase mimetic property, 50 microM MnTBAP was found to attenuate the injury produced dose-dependently by exposure to various concentrations of paraquat for 4 h. MnTBAP also protected endothelial cells in a dose-dependent manner against paraquat. The protective effect of MnTBAP appears to be caused by its intracellular superoxide-scavenging activity because neither the zinc form nor CuZnSOD protected the cells against paraquat-induced injury.[1] |
| In vivo | Local administration of MnTBAP significantly and reduced carrageenan-induced paw oedema dose-dependently at all time points, which was related to its superoxide dismutase mimetic property. MnTBAP also caused a significant dose-dependent reduction in paw myeloperoxidase activity, as well as preventing histological injury. Immunohistochemical analyses for nitrotyrosine showed a positive staining in paw from carrageenan-treated rats.[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (4.57 mM), Sonication is recommended.
DMSO : 90 mg/mL (102.72 mM), Sonication is recommended.
0.5 M NaOH : 18 mg/mL (20.54 mM), Sonication is recommended.
1M NaOH : 9 mg/mL (10.27 mM), when pH is adjusted to 8 with NaOH. Sonication is recommended.
|
| Keywords | NF-κB | NFκB | NF-kB | NFkB | MnTBAP Chloride | Antioxidant |
| Inhibitors Related | Sodium propionate | Ethyl palmitate | Kojic acid | Uridine | Fumaric acid | AFMK | 1,4-Naphthoquinone | Glucosamine | Ethyl linoleate | L-Cystine | N,N-Dimethylacetamide | Magnesium sulfate |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | NF-κB Signaling Compound Library | Bioactive Compound Library | HIF-1 Signaling Pathway Compound Library | Anti-Ovarian Cancer Compound Library | Anti-Breast Cancer Compound Library | Anti-Fibrosis Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Transcription Factor-Targeted Compound Library |
United States
