| Name | Monensin sodium salt |
| Description | Monensin sodium is an antiprotozoal agent produced by Streptomyces cinnamonensis.Monensin sodium salt (Monensin A sodium salt) causes a marked enlargement of the MVBs and regulates exosome secretion |
| In vitro | Monensin sodium salt (Coban), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. Monensin is an ionophore related to the crown ethers with a preference to form complexes with monovalent cations such as: Li+, Na+, K+, Rb+, Ag+, and TI+. [1] Monensin A is able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport, and exhibits antibiotic, antimalarial, and other biological activities. [2] The antibacterial properties of monensin and its derivatives are a result of their ability to transport metal cations through cellular and subcellular membranes. [3] |
| In vivo | LD50: Mice 335 mg/kg (i.g.) [4]; Rats 36.5 mg/kg (i.g.); Chickens 185 mg/kg (i.g.). [5] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 12.5 mg/mL (18.04 mM), Sonication is recommended.
DMSO : < 1 mg/mL (insoluble or slightly soluble)
10% EtOH+90% Corn Oil : 1 mg/mL (1.44 mM), Sonication is recommended.
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| Keywords | Sodium-hydrogen Exchanger | SodiumChannel | Sodium/hydrogen Exchanger | Sodium Channel | Na+/H+ Exchanger (NHE) | Monensin sodium salt | Monensin sodium | Monensin A sodium | Monensin A | Monensin | Inhibitor | inhibit | Bacterial | Antibiotic | Antibacterial |
| Inhibitors Related | Neomycin sulfate | Calcium Propionate | Aceglutamide | D(+)-Raffinose pentahydrate | Benzyl propionate | Ethyl linoleate | Fenpyroximate | Formamide | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Anti-Parasitic Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Anti-Fungal Compound Library | Natural Product Library | Microbial Natural Product Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Ion Channel Targeted Library |
United States
