| Name | Montelukast sodium |
| Description | Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury. |
| Cell Research | Nasal mucosa and polyp epithelial cells are stimulated with fetal bovine serum (FBS) with or without MK for 24 hours, and cytokine concentrations in epithelial secretions are measured by ELISA. After incubating peripheral blood eosinophils with epithelial cell-conditioned media (ECM) with or without montelukast up to 3 days, eosinophil survival is assessed by Trypan blue dye exclusion[1]. |
| In vitro | Administering 6 mg/kg of Montelukast once daily for 20 days significantly inhibits the increase of eosinophils in both the BAL fluid and lung tissue in mice stimulated by OVA, while also elevating the IL-5 levels in the BAL fluid. OVA stimulation leads to an upsurge in CysLT1 receptor mRNA expression but a decrease in CysLT2 receptor mRNA expression. Following OVA stimulation, Montelukast suppresses the elevated expression of CysLT1 without diminishing the expression of CysLT2. |
| In vivo | Montelukast acts by binding to the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchi, thereby blocking the effects of leukotriene D4. This action prevents airway edema, smooth muscle contraction, and secretion of viscous liquids, reduces bronchoconstriction caused by leukotrienes, and diminishes inflammation occurrence. |
| Storage | Pure form: -20°C for 3 years
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 30.4 mg/mL (49.99 mM), Sonication is recommended. (The compound is unstable in solution, please use soon.)
DMSO : 250 mg/mL (411.07 mM), Sonication is recommended. The compound is unstable in solution, please use soon.
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| Keywords | Montelukast sodium | Montelukast | MK-0476 | MK 0476 | liver | LeukotrieneReceptor | Leukotriene Receptor | leukotriene | ischemia–reperfusion | intestinal | injury | Inhibitor | inhibit | icardiac | damage | cysteinyl | Cysltr1 | asthma | antioxidant |
| Inhibitors Related | LTB4-IN-1 | L 674573 | Olsalazine disodium | Pirodomast | Pranlukast | CGP 35949 | Bestatin | Tebufelone | ABT-080 | LTβR-IN-1 | Darbufelone mesylate | Ticolubant |
United States
