| Name | Moslosooflavone |
| Description | Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone significantly inhibits the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages. |
| Animal Research | The chemical constituents, isolated and purified by column chromatography from Saussurea invo lucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice[2]. |
| In vitro | 5-hydroxy-7,8-dimethoxyflavone significantly decreased TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and nitric oxide (NO) secretions from LPS/IFN-gamma stimulated RAW 264.7 cells[1]. |
| In vivo | 5-hydroxy-7,8-dimethoxyflavone can significantly prolong the survival time of hypoxic mice[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 10 mg/mL (33.52 mM), Sonication is recommended.
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| Keywords | ReactiveOxygenSpecies | Reactive Oxygen Species | NF-κB | NFκB | NF-kB | NFkB | Moslosooflavone | Inhibitor | inhibit | flavonoid | anti-inflammatory | anti-hypoxia |
| Inhibitors Related | Ethoxyquin | Kaolin | Allopurinol | Cysteamine hydrochloride | Kojic acid | 1,4-Naphthoquinone | Ethyl linoleate | Magnesium acetate tetrahydrate | L-Cystine | N,N-Dimethylacetamide | L-Ascorbic acid sodium salt | Dimethyl phthalate |
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