| Name | MT 63-78 |
| Description | MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM) that blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. It has antitumor effects and induces cell mitotic arrest and apoptosis. |
| In vitro | MT 63-78 (0-50 μM; 24 hours; LNCaP, PC3, C4-4, C4-2B, CL1 and 22RV1 cells) treatment induces a reduction of anti-apoptotic Mcl-1 and an accumulation of the pro-apoptotic BH3-only protein Puma. MT 63-78 (0-50 μM; 4 days; LNCaP and PC3 cells) treatment displays a dose-dependent decrease in cell number and activation of AMPK signaling. MT 63-78 (0-50 μM; 30 minutes; LNCaP and PC3 cells) treatment shows dose-dependent phosphorylation of AMPK targets Acetyl-CoA Carboxylase (ACC) on Ser79 and Raptor on Ser792, and increases Thr172 phosphorylation on the AMPK α subunit. MT 63-78 (25 μM; 24 hours; LNCaP and CRPC cells) treatment causes significant enrichment in the G2/M population. |
| In vivo | MT 63-78 (30 mg/kg; intraperitoneal injection; daily; for 14 days; C57 BL/6 male mice) treatment results in a 33% inhibition of tumor growth. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 3.27 mg/mL (10.02 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (3.06 mM), Sonication is recommended.
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| Keywords | Thr172 | Raptor | p53 | mTORC1 | mTOR | MT 63-78 | MT 6378 | MT 63 78 | mitotic | Mcl-1 | Mammalian target of Rapamycin | lipogenesis | Inhibitor | inhibit | direct | dephosphorylation | BH3 | arrest | Apoptosis | antitumor | AMPK | AMP-activated protein kinase |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Chitosan oligosaccharide | Sildenafil citrate |
| Related Compound Libraries | Glycometabolism Compound Library | Bioactive Compound Library | Antidepressant Compound Library | Kinase Inhibitor Library | Antioxidant Compound Library | Neuroprotective Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | AMPK-Targeted Compound Library | Anti-Hypertension Compound Library |
United States
