| Name | Mulberrofuran C |
| Description | Mulberrofuran C, a benzofuran present in Morus alba, has inhibitory effects on Aβ₁₋₄₂ auto-aggregation, tau protein aggregation, AChE, antioxidant activity and neuroprotective effects, and has anti-Alzheimer's disease potential. |
| In vitro | Mulberrofuran C (Compound 2) exhibited multi-target in vitro activities relevant to Alzheimer’s disease. At 20 μM, Mulberrofuran C inhibited Aβ₁₋₄₂ self-aggregation by 70.7%, comparable to resveratrol (72.8%) and stronger than methylene blue (33.5%). Mulberrofuran C also suppressed tau protein aggregation (49.1% inhibition) and demonstrated strong antioxidant activity (ORAC value: 2.9, higher than Trolox). In cholinesterase inhibition assays, Mulberrofuran C showed moderate AChE inhibition (IC₅₀ = 4.2 μM), and in LPS-induced BV2 microglial cells, Mulberrofuran C suppressed NO production with an IC₅₀ of 21.8 μM [1]. Mulberrofuran C (Compound 2) exhibited in vitro antiviral activity against herpes simplex viruses HSV-1 and HSV-2 in Vero cells. In plaque reduction assays, Mulberrofuran C showed IC₅₀ values of 5.0, 3.1, and 3.2 μg/mL against HSV-1 (standard strain), HSV-1 (clinical strain), and HSV-2, respectively. The cytotoxic concentration (CC₅₀) of Mulberrofuran C was 28.0 μg/mL, yielding selectivity indices between 5.6 and 8.9, indicating moderate antiviral efficacy with acceptable cytotoxicity[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | HSV |
| Inhibitors Related | Flubendazole | Maltol | AFMK | Valproic Acid | DL-alpha-Tocopherylacetate | α-Cyclodextrin | L-Cystine | γ-Terpinene | Methylene Blue trihydrate | Dimethyl sulfoxide | Coumaran | Tyrosol |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Antioxidant Compound Library | Multi-Target Compound Library | Stem Cell Differentiation Compound Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | High-Efficiency Gene Editing Small Molecule Library |
United States
