| Name | Myricitrin |
| Description | Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects. |
| In vitro | In mice, Myricitrin (10/30 mg/kg, i.p.) blocks apomorphine-induced stereotypy and climbing behaviors, while also prolonging the hindlimb withdrawal time. |
| In vivo | In rodent models of chemical and mechanical pain, Flurbiprofen activates protein kinase Cα and PKCε, while Myricitrin blocks this action, thereby exerting a significant analgesic effect. The pain-relief mechanism of Myricitrin is attributed to a decrease in calcium ion influx and the opening of voltage-dependent and small-conductance calcium-activated potassium (K+) channels. Additionally, Myricitrin inhibits the expression of the p53 gene, which leads to the activation of caspase-3 and the MAPK signaling pathway, while altering the expression pattern of anti-apoptotic and pro-apoptotic genes. Consequently, this reduces H₂O₂-induced apoptosis in vascular endothelial cells. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble)
10% DMSO+90% Saline : 3.3 mg/mL (7.11 mM), Sonication is recommended.
DMSO : 86 mg/mL (185.19 mM), Sonication is recommended.
Ethanol : 1 mg/mL (2.15 mM), Sonication is recommended.
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| Keywords | PKCε | PKCα | Myricitrin | Inhibitor | inhibit | antioxidant |
| Inhibitors Related | Kaolin | Gum arabic | Kojic acid | Hydroxychloroquine | Metronidazole | Avermectin B1a | 2-Amino-2-methyl-1-propanol | Doxycycline | 1,8-Cineole | Fenpyroximate | Methylene Blue trihydrate | Gluconate Calcium |
| Related Compound Libraries | Polyphenolic Natural Product Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Natural Product Library | Miao medicine Compound Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Food as Medicine Compound Library | TGF-beta/Smad Compound Library |
United States
