Myristyl nicotinate
Modify Date: 2024-01-09 11:33:36
 Myristyl nicotinate structure | Common Name | Myristyl nicotinate |
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| CAS Number | 273203-62-6 | Molecular Weight | 319.48200 |
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| Density | 0.953g/cm3 | Boiling Point | 411.7ºC at 760 mmHg |
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| Molecular Formula | C20H33NO2 | Melting Point | N/A |
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| MSDS | N/A | Flash Point | 202.8ºC |
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Use of Myristyl nicotinate
Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier[1][2]. |
Names
| Name | tetradecyl pyridine-3-carboxylate |
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| Synonym | More Synonyms |
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Myristyl nicotinate Biological Activity
| Description | Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier[1][2]. |
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| Related Catalog | Research Areas >> Cancer Signaling Pathways >> Others >> Others |
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| In Vitro | Myristyl nicotinate (Tetradecyl nicotinate) is used for treatment and prevention of conditions that involve skin barrier impairment such as chronic photodamage and atopic dermatitis or for mitigating skin barrier impairment that results from therapy such as retinoids or steroids[2]. |
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| References | [1]. Catz P, et al. Simultaneous determination of myristyl nicotinate, nicotinic acid, and nicotinamide in rabbit plasma by liquid chromatography-tandem mass spectrometry using methyl ethyl ketone as a deproteinization solvent. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Dec 27;829(1-2):123-35. [2]. Jacobson MK, et al. Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage. Exp Dermatol. 2007 Nov;16(11):927-35. |
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Chemical & Physical Properties
| Density | 0.953g/cm3 |
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| Boiling Point | 411.7ºC at 760 mmHg |
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| Molecular Formula | C20H33NO2 |
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| Molecular Weight | 319.48200 |
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| Flash Point | 202.8ºC |
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| Exact Mass | 319.25100 |
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| PSA | 39.19000 |
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| LogP | 5.93950 |
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| Vapour Pressure | 5.46E-07mmHg at 25°C |
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| Index of Refraction | 1.486 |
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