PRODUCT INFORMATION
| Common Name | Myxothiazol |
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| CAS Number | 76706-55-3 | Molecular Weight | 487.67800 |
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| Density | 1.158g/cm3 | Boiling Point | 679.6ºC at 760 mmHg |
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| Molecular Formula | C25H33N3O3S2 | Melting Point | N/A |
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| MSDS | ChineseUSA | Flash Point | 364.8ºC |
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| Symbol | 
GHS06 | Signal Word | Danger |
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Use of Myxothiazol
Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[1][2]. |
Properties
Articles39
Spectrum
Names
| Name | myxothiazol |
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| Synonym | More Synonyms |
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Myxothiazol Biological Activity
| Description | Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[1][2]. |
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| Related Catalog | Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal |
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| In Vitro | Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[2]. Myxothiazol binds to the ubiquinol oxidation site Qo of complex III and blocks electron transfer from ubiquinol to cytochrome b and thus inhibits complex III activity[3]. |
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| In Vivo | Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality[3]. Animal Model: C57Bl/J6 mice[3] Dosage: 0.56 mg/kg Administration: I.p.; 24 hours intervals for at most 4 times Result: A reversible complex III activity decrease to 50% of control value occurred at 2 h post-injection. At 74 h only minor histological changes in the liver were found, supercomplex formation was preserved and no significant changes in the expression of genes indicating hepatotoxicity or inflammation were found. |
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| References | [1]. Thierbach G, et al. Myxothiazol, a new antibiotic interfering with respiration. Antimicrob Agents Chemother. 1981;19(4):504-507. [2]. von Jagow G,et al. An inhibitor of mitochondrial respiration which binds to cytochrome b and displaces quinone from the iron-sulfur protein of the cytochrome bc1 complex. J Biol Chem. 1984;259(10):6318-6326. [3]. Davoudi M, et al. A mouse model of mitochondrial complex III dysfunction induced by myxothiazol. Biochem Biophys Res Commun. 2014;446(4):1079-1084. |
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Chemical & Physical Properties
| Density | 1.158g/cm3 |
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| Boiling Point | 679.6ºC at 760 mmHg |
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| Molecular Formula | C25H33N3O3S2 |
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| Molecular Weight | 487.67800 |
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| Flash Point | 364.8ºC |
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| Exact Mass | 487.19600 |
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| PSA | 143.81000 |
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| LogP | 6.51870 |
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| Index of Refraction | 1.584 |
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| Storage condition | -20°C |
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Toxicological Information
CHEMICAL IDENTIFICATIONCHEMICAL NAME : 2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)- 4-yl)-3,5-dimethoxy- 4-methyl-
CAS REGISTRY NUMBER : 76706-55-3
MOLECULAR FORMULA : C25-H33-N3-O3-S2
HEALTH HAZARD DATAACUTE TOXICITY DATAROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 33,1474,1980
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Safety Information
| Symbol |
GHS06 |
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| Signal Word | Danger |
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| Hazard Statements | H300 |
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| Precautionary Statements | P264-P301 + P310 |
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| Hazard Codes | T+ |
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| Risk Phrases | 28 |
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| Safety Phrases | 28-36/37-45 |
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| RIDADR | UN 3462 6.1/PG 1 |
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| Packaging Group | III |
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| Hazard Class | 6.1(b) |
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![4-(2''-benzothiazolyl)sulfonylmethyl-2'-[(1'''S),6'''-dimethylhepta-(2'''E),(4'''E)-dienyl]-2,4'-bithiazole structure](https://image.chemsrc.com/caspic/398/1093126-36-3.png)
