| Name | N-Acetyl lysyltyrosylcysteine amide |
| Description | N-Acetyl lysyltyrosylcysteine amide is a non-toxic, potent, reversible, and specific myeloperoxidase (MPO) tripeptide inhibitor that effectively inhibits MPO production in vivo, attenuates neuronal damage, preserves brain tissue and neurological function post-stroke, and inhibits MPO-dependent hypochlorite (HOCl) production, protein nitration, and LDL oxidation. It is also used in the study of bronchial dysplasia. |
| In vivo | N-Acetyl lysyltyrosylcysteine amide (KYC) (10 mg/kg; i.p.; daily for 3-7 days; C57BL/6J mice) significantly reduces neurological severity scores and infarct size in MCAO mice.[1]
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 7 days) significantly protects BBB function and decreased neutrophil infiltration.[1]
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 7 days; C57BL/6J mice) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice.[1]
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days; C57BL/6J mice) decreases apoptosis and cell injury in the brains of MCAO mice.[1]
N-Acetyl lysyltyrosylcysteine amide reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduces NO2Tyr and 4-HNE in MCAO mice. N-Acetyl lysyltyrosylcysteine amide significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice.[1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 55 mg/mL (121.26 mM), Sonication is recommended.
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| Keywords | N-Acetyl lysyltyrosylcysteine Amide | NAcetyl lysyltyrosylcysteine amide | N Acetyl lysyltyrosylcysteine amide | MPO | GlutathionePeroxidase | Glutathione Peroxidase |
| Inhibitors Related | AZD8309 | ML-210 | (±)-Methyl Jasmonate | 4-Aminosalicylic acid | 2-Acetamidophenol | PF-1355 | Sodium 2-mercaptoethanesulfonate | 5-Aminosalicylic Acid | Melatonin | 4-Methylesculetin | Probucol | Cefdinir |
| Related Compound Libraries | Bioactive Compound Library | Glutamine Metabolism Compound Library | Multi-Target Compound Library | Peptide Compound Library | Inhibitor Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
United States
