| Name | N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride |
| Description | N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride) is an inhibitor of trypsin-like protease and exhibits an inhibitory effect on IFN-γ activities. |
| In vitro | A lower concentration of anti-Fas (10 ng/mL) is used to examine the interaction among the three effectors simultaneously, that is, anti-Fas, TLCK, and IFN-γ. N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (50 μM) exhibits a small decrease in cell viability. Beyond 50 μM, a dose-dependent decrease in cell viability is observed. IFN-γ slightly reduces cell viability on its own. The addition of anti-Fas (10 ng/mL) results in a slight decrease in cell survival, which is enhanced more than additively in the presence of TLCK, most prominently between 50 and 100 μM. Upon addition of both anti-Fas and IFN-γ, a decrease (≈46%) in cell viability is observed. Moreover, the decrease in cell survival is further enhanced by the addition of higher concentrations of TLCK, 25 μM, and more[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 95 mg/mL (257.24 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (13.54 mM), Sonication is recommended.
DMSO : 245 mg/mL (663.4 mM), Sonication is recommended.
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| Keywords | Trypsin-like proteasomes | NalphaTosylLlysine chloromethyl ketone hydrochloride | N alpha Tosyl L lysine chloromethyl ketone hydrochloride | Inhibitor | inhibit | IFN-γ |
| Inhibitors Related | Boc-Lys(Boc)-OH | Aceglutamide | Acetaminophen | Phenidone | Sodium lauroyl glutamate | Indomethacin | L-Ornithine L-aspartate | Fmoc-Aib-OH | Trometamol | H-Glu(OEt)-OEt.HCl | Fmoc-Lys(Alloc)-OH | Magnesium sulfate |
| Related Compound Libraries | Cysteine Covalent Library | Pain-Related Compound Library | Bioactive Compound Library | Cytokine Inhibitor Library | Ubiquitination Compound Library | Neuronal Signaling Compound Library | Hematonosis Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library |
United States
