N-Methylolacrylamide NEW

• DATA ITEMS CITED :

• 27

• MOLECULAR FORMULA :

• C4-H7-N-O2

• MOLECULAR WEIGHT :

• 101.12

• WISWESSER LINE NOTATION :

• Q1MV1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 474 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 563 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 420 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Administration onto the skin

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 16 gm/kg

• TOXIC EFFECTS :

• Behavioral - tremor

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 8736 mg/kg/27W-C

• TOXIC EFFECTS :

• Behavioral - muscle weakness

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 2400 mg/kg/16D-I

• TOXIC EFFECTS :

• Related to Chronic Data - death

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 3250 mg/kg/13W-I

• TOXIC EFFECTS :

• Behavioral - ataxia Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - changes in testicular weight

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 4688 mg/kg/8W-I

• TOXIC EFFECTS :

• Related to Chronic Data - changes in testicular weight

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 1625 mg/kg/13W-I

• TOXIC EFFECTS :

• Behavioral - ataxia Liver - changes in liver weight Related to Chronic Data - changes in testicular weight

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 4800 mg/kg/16D-I

• TOXIC EFFECTS :

• Related to Chronic Data - death

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 25750 mg/kg/2Y-C

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 4608 mg/kg

• SEX/DURATION :

• male 16 day(s) pre-mating

• TOXIC EFFECTS :

• Reproductive - Paternal Effects - testes, epididymis, sperm duct

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 730 gm/kg

• SEX/DURATION :

• male 6 week(s) pre-mating

• TOXIC EFFECTS :

• Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 730 gm/kg

• SEX/DURATION :

• male 6 week(s) pre-mating

• TOXIC EFFECTS :

• Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

• TYPE OF TEST :

• Sperm Morphology

MUTATION DATA

• TYPE OF TEST :

• Sister chromatid exchange

• TEST SYSTEM :

• Rodent - hamster Ovary

• DOSE/DURATION :

• 250 mg/L

• REFERENCE :

• NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-352,1989 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,435,1994 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,435,1994 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,435,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81901 No. of Facilities: 154 (estimated) No. of Industries: 7 No. of Occupations: 17 No. of Employees: 2938 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81901 No. of Facilities: 117 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 20665 (estimated) No. of Female Employees: 13852 (estimated)