N-Nitroso Esmolol
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E-mail: anna@molcoo.com
Product Information
Product Number: N031094
English Name: N-Nitroso Esmolol
English Alias: methyl 3-(4-(2-hydroxy-3-(isopropyl(nitroso)amino)propoxy)phenyl)propanoate
CAS Number: None
Molecular Formula: C16H24N2O5
Molecular Weight: 324.37
Advantages: As a reference standard for N-Nitroso Esmolol, it has a clear and precise chemical structure, and has undergone strict purity identification and quality control, showing good stability under different storage environments and experimental conditions. It can be used as a reliable reference substance, providing an accurate basis for the detection of N-nitroso impurities in esmolol bulk drugs and formulations, ensuring the high precision and repeatability of detection results. It helps pharmaceutical companies and research institutions to meet strict standards in drug quality control and satisfy the quality requirements in the process of drug research and development and production.
Applications: It is mainly used in the quality research, impurity analysis, and quality control of esmolol bulk drugs and formulations. It is used to establish and validate impurity detection methods such as high-performance liquid chromatography (HPLC) and liquid chromatography - mass spectrometry (LC - MS). In the research and development process of esmolol, it helps to study the source and formation mechanism of N-nitroso impurities, and optimize the synthesis process to reduce impurity generation. In the production process, it is used to monitor the content of N-Nitroso Esmolol in products in real time to ensure that drug quality meets relevant standards and regulatory requirements. It can also be used to evaluate the changes of impurities in esmolol drugs during storage and transportation, providing data support for drug stability research.
Background Description: Esmolol is a β-blocker used for rapidly controlling heart rate and treating hypertension and other conditions. In the process of its production and research and development, the presence of nitroso impurities may pose a potential carcinogenic risk and negatively impact the safety and effectiveness of the drug. To ensure the safety of patients' medication and meet the strict control requirements of drug regulatory authorities for nitrosamine impurities, in-depth research and precise control of N-nitroso impurities in esmolol are essential. As one of the nitroso impurities of esmolol, the study of N-Nitroso Esmolol helps to improve the quality standard system of esmolol, enhance drug quality, and reduce medication risks.
Research Status: Currently, the research on N-Nitroso Esmolol mainly focuses on the optimization and improvement of impurity detection methods. By using more advanced instruments and detection technologies, such as high-resolution mass spectrometry and ultra-high-performance liquid chromatography, the sensitivity and accuracy of detecting trace N-nitroso impurities are improved. At the same time, researchers are actively exploring the source and change rules of this impurity during the synthesis and storage of esmolol, and reducing the generation and accumulation of impurities from multiple aspects, including raw material selection, reaction condition control, and storage environment optimization. In addition, the research on the potential impact of this impurity on the performance and safety of esmolol drugs is also gradually deepening. The toxicity is evaluated through in vitro and in vivo experiments to provide a scientific basis for formulating reasonable impurity limit standards.
NOTE！
We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!
WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com
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