N-Nitrososarcosine Methyl Ester
Product Code：L030047
English Name：N-Nitrososarcosine Methyl Ester
English Alias：methyl 2-(methyl(nitroso)amino)acetate
CAS No.：51938-19-3
Molecular Formula：C₄H₈N₂O₃
Molecular Weight：132.12
High-Purity Reference Standard：Confirmed by HPLC (≥99.0%), NMR (1H, 13C), and HRMS, suitable for precise analysis of N-nitroso impurities.
Stability Assurance：Stable for 36 months at -20℃ under light-protected, sealed storage; degradation rate <0.1% in methanol-water solution within 6 months.
Quality Control Testing：Used for UPLC-MS/MS detection of N-nitroso impurities in food, pharmaceuticals, and cosmetics, controlling content to meet international regulatory standards (e.g., ≤10 μg/kg in food).
Environmental Monitoring：Detects N-Nitrososarcosine Methyl Ester in drinking water, soil, and industrial wastewater via solid-phase extraction coupled with GC-MS, achieving an LOD of 0.1 ng/L.
Process Optimization Research：Monitors N-Nitrososarcosine Methyl Ester formed by nitrosation side reactions during amino acid ester synthesis, reducing generation by >70% by adjusting reaction temperature (e.g., 5-10℃) and avoiding nitrite exposure.
N-nitroso compounds (NOCs) are known carcinogens prevalent in the environment, food processing, and chemical products. N-Nitrososarcosine Methyl Ester, as a type of NOC, may form during production of sarcosine ester-containing raw materials through reactions between amino groups and nitrites or spontaneous nitrosation under acidic or high-temperature storage conditions. Its nitrosamide group is genotoxic. With stricter regulations on NOCs by WHO, FDA, studying such impurities is crucial for ensuring food and environmental safety.
Detection Technology：GC-MS/MS with a DB-5MS column (30m×0.25mm×0.25μm) and selected ion monitoring (SIM) mode achieves separation within 6 minutes, with an LOD of 0.05 ng/L for trace analysis.
Formation Mechanism：Formed by reaction of sarcosine methyl ester with sodium nitrite under acidic conditions (pH<4); optimizing reaction pH (neutral) and adding antioxidants (e.g., vitamin C) inhibits its formation.
Safety Evaluation：Animal studies show carcinogenicity, with a permitted daily intake (TTC value) determined as 1.5 μg/day. Accelerated stability testing is ongoing to monitor nitrosation rates under different humidity and light conditions.
We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!
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E-mail: anna@molcoo.com
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