| Name | N-(p-Coumaroyl) serotonin |
| Description | N-(p-Coumaroyl) Serotonin, a polyphenol isolated from the seeds of safflower, exhibits antioxidant, cardioprotective effects after ischemia, and antitumor activity. It may improve vascular distensibility and reduce cardiovascular risk. N-(p-Coumaroyl) Serotonin ameliorates atherosclerosis and distensibility of the aortic wall in vivo, and is commonly used in atherosclerosis research. |
| In vitro | As reactive oxygen species (ROS) are implicated in the signaling of lipopolysaccharide (LPS), we examined whether CS has a suppressive effect on inflammatory cytokine generation from human monocytes in vitro. CS at 50-200 microM reduced tumor necrosis factor (TNF), interleukin-1 (IL-1), and IL-6 activities in the culture supernatants from LPS-stimulated human blood monocytes without cytotoxicity. ELISA assay revealed that the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 was inhibited by CS. Northern blot analysis showed that LPS-induced expression of these cytokine mRNA in monocytes was suppressed by CS. NF-kappaB activation was also inhibited by CS[1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (6.2 mM), Sonication is recommended.
DMSO : 66.67 mg/mL (206.82 mM), Sonication is recommended.
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| Keywords | VSMC | TNF-α | ROS | Platelet-derived growth factor receptor | PDGFR | NF-κB | N-(p-Coumaroyl) serotonin | N(pCoumaroyl) serotonin | N (p Coumaroyl) serotonin | Inhibitor | inhibit | dysfunction | distensibility | atherosclerosis | aortic wall | anti-inflammatory |
| Inhibitors Related | TBHQ | Urea | Gum arabic | L-Cysteine | Sorafenib | Lactose | Magnesium acetate tetrahydrate | Cystamine dihydrochloride | Copper Sulfate Pentahydrate | Tauroursodeoxycholate | Gluconate Calcium | Pazopanib |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Polyphenolic Natural Product Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library |
United States
