| Name | Nω-Propyl-L-arginine hydrochloride |
| Description | Nω-Propyl-L-arginine hydrochloride is a highly selective and competitive neuronal nitric oxide synthase inhibitor with nanomolar affinity and marked selectivity over endothelial nitric oxide synthase, making Nω-Propyl-L-arginine hydrochloride a precise pharmacological tool for investigating nitric oxide signaling, neuronal regulation, and neurovascular function. |
| In vivo | In male NMRI mice, systemic administration of Nω-Propyl-L-arginine hydrochloride (20 mg/kg, i.p.) modulates behavioral responses in models of psychiatric impairment. The compound blocks behavioral deficits induced by Phencyclidine (PCP), specifically reducing PCP-induced disruptions in prepulse inhibition (PPI), a measure of sensorimotor gating. Additionally, it reduces the stimulation of locomotor activity caused by PCP. Beyond neurobehavioral models, the substance is used in renal physiology to study the regulation of renal blood flow and interstitial nitric oxide levels, helping to clarify the role of nNOS in kidney function [2][3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 20 mg/mL (79.13 mM), Sonication is recommended.
H2O : 20 mg/mL (79.13 mM), Sonication is recommended.
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| Keywords | Nω-Propyl-L-arginine Hydrochloride | NωPropylLarginine hydrochloride | Nω Propyl L arginine hydrochloride | Nw-Propyl-L-arginine Hydrochloride | Nomega-Propyl-L-arginine Hydrochloride |
| Inhibitors Related | Miconazole | MSU-42011 | Aminoguanidine hydrochloride | L-NAME hydrochloride | EIT hydrobromide | Dexamethasone acetate | S-Methylisothiourea sulfate | Cannabigerol | 1400W dihydrochloride | Flavone | Diallyl disulfide | 7-Nitroindazole |
| Related Compound Libraries | Bioactive Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
