| Name | NBQX disodium |
| Description | NBQX disodium is a highly selective, competitive AMPA receptor antagonist with neuroprotective and anticonvulsant activity. NBQX disodium is a salt of NBQX. NBQX disodium is a potent and selective AMPA/rhodosinate receptor antagonist that can be used to antagonize the excitatory toxicity of glutamate. It has anticonvulsant effects in rodent models. |
| In vitro | In HIP-009 cells, NBQX disodium salt inhibited both AMPA or kainic acid (KA) induced signals in a concentration-dependent manner, with IC50 values being 0.7 ± 0.1 and 0.7 ± 0.03 μM, respectively. The AMPA-evoked calcium rise was completely inhibited by NBQX disodium salt, whereas 68.6% ± 1.3% inhibition of the KA-induced signal was observed with 30 μM of NBQX disodium salt treatment.[1] |
| In vivo | Administration of NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) exhibits a reduction in PTZ-induced seizures. [2]
In a rat model of focal ischemia, NBQX disodium demonstrates neuroprotective effects when administered intravenously as a bolus dose of 30 mg/kg at the time of MCA occlusion, followed by an additional dose at 1 hour post-occlusion. [3] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 30 mg/mL (78.9 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.26 mM), Sonication is recommended.
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| Keywords | NBQX Disodium | NBQX | FG-9202 | FG9202 | FG 9202 | AMPA |
| Inhibitors Related | Urethane | Decanoic Acid | N-Methylsarcosine | L-Glutamic acid | N,N-Dimethylglycine hydrochloride | L-Phenylalanine | glycine | Indole-2-carboxylic acid | L-Glutamine | L-Glutamic acid monosodium salt | Memantine | Memantine hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Glutamine Metabolism Compound Library | Neurotransmitter Receptor Compound Library | Neuroprotective Compound Library | Inhibitor Library | Bioactive Compounds Library Max |
United States
