| Name | Neohesperidin Dihydrochalcone |
| Description | Neohesperidin Dihydrochalcone (Neohesperidin DC) is an artificial sweetener derived from citrus. |
| Cell Research | WST-8 dye is used in the cell viability assay. HIT-T15 and HUVEC cells are grown and maintained in Dulbecco's modified Eagle's medium, supplemented with 10% fetal bovine calf serum. 1000 cells in each well are incubated with various concentrations of neohesperidin dihydrochalcone (50, 100, 500 μM, 1 mM) and other compounds. After treating HIT-T15 and HUVEC cells with 500 μM HOCl, WST-8 dye is added to each well, and the absorbance is detected at 420 nm with microplate reader[1]. |
| In vivo | Administration of neohesperidin dihydrochalcone significantly reduces the activities of AST and ALT, both key markers of liver damage. It also inhibits the expression of NF-κB, IL-6, IL-1β, and TNF-α proteins, which are elevated in the liver of PQ-treated mice, indicating its potential protective effects on liver inflammation and damage[3]. Furthermore, studies on Wistar Crl:(WI)WU BR rats to assess the embryotoxicity and teratogenicity of neohesperidin dihydrochalcone reveal no adverse effects at dietary levels up to 5%, the highest dose investigated. At this level, rats consumed approximately 3.3 g/kg body weight/day[4], demonstrating the compound's safety at significant dosage levels. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 100 mg/mL (163.24 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.26 mM), Sonication is recommended.
DMSO : 50 mg/mL (81.62 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
|
| Keywords | ReactiveOxygenSpecies | Reactive Oxygen Species | Neohesperidin Dihydrochalcone | Inhibitor | inhibit |
| Inhibitors Related | Ethoxyquin | Kaolin | Allopurinol | Cysteamine hydrochloride | Ethyl linoleate | Magnesium acetate tetrahydrate | Inosine | L-Cystine | Copper Sulfate Pentahydrate | Dimethyl itaconate | L-Ascorbic acid sodium salt | Dimethyl phthalate |
| Related Compound Libraries | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Anti-Neurodegenerative Disease Compound Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Saccharide and Glycoside Natural Product Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Anti-Aging Compound Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | Food as Medicine Compound Library |
United States
