| Name | Neohesperidin |
| Description | Neohesperidin (NSC-31048) with antioxidant and neuroprotective properties. Unlike other citrus flavanones, it does not inhibit oral carcinogenesis in a rat model. |
| In vivo | Neohesperidin, administered at a dose of 50 mg/kg, significantly reduces the occurrence of HCl/ethanol-induced gastric lesions by 55.0%. In studies involving pylorus-ligated rats, this compound notably decreases both the volume of gastric secretion and gastric acid output, while simultaneously increasing gastric pH[1]. Additionally, neohesperidin treatment markedly improves glucose metabolism and insulin sensitivity in diabetic mice, evidenced by substantial reductions in fasting glucose, serum glucose, glycosylated serum protein (GSP), serum triglycerides, total cholesterol, and leptin levels, alongside a decrease in the liver index. It also enhances oral glucose tolerance and reduces insulin resistance in these mice[3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (163.78 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (6.55 mM), Sonication is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | NSC-31048 | NSC31048 | Neohesperidin | Inhibitor | inhibit | antioxidant |
| Inhibitors Related | Thiamine monochloride | Urea | Maltol | AFMK | DL-alpha-Tocopherylacetate | Sulbutiamine | Ethyl linoleate | L-Cystine | γ-Terpinene | Tyrosol | 4-hydroxyphenylacetic acid | Trolox |
| Related Compound Libraries | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Neuroprotective Compound Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ancient Chinese Classical Formulas Compound Library |
United States
