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ChemicalBook Product Catalog Biochemical Engineering Chinese Herbs Nepodin

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Nepodin NEW

$52.00 1mg

$129.00 5mg

$213.00 10mg

Min. Order
Purity98.50%
Cas No3785-24-8
Supply Ability10g
Update time2026-04-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

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Chemical Properties

Product Name	Nepodin
CAS No	3785-24-8
EC-No
Min. Order
Purity	98.50%
Supply Ability	10g
Release date	2026/04/13

Product Introduction

Bioactivity

Name	Nepodin
Description	Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, which is at least partly mediated by stimulation of GLUT4 translocation via AMPK activation by nepodin.
In vitro	To obtain a novel modulator of glucose metabolism, we conducted screening of a small compound library in cultured L6 myotubes. We identified Nepodin that stimulated glucose uptake dose-dependently in differentiated L6 myotubes. The stimulatory effect of Nepodin on glucose uptake was abrogated by a 5'-adenosine monophosphate-activated protein kinase (AMPK) inhibitor. In addition, Nepodin stimulated the phosphorylation of AMPK. Nepodin also stimulated the translocation of GLUT4 to the plasma membrane in L6 myoblasts transfected with a Glut4 cDNA-coding vector and in differentiated L6 myotubes. In in vivo study, Nepodin suppressed the increases in fasting blood glucose levels and improved the glucose intolerance of C57BL/KsJ-db/db mice, a type 2 diabetic animal model. Nepodin rescued the impaired phosphorylation of AMPK in the skeletal muscle of db/db mice[1]
Storage	Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 150 mg/mL (693.71 mM), Sonication is recommended.
Keywords	Parasite \| Nepodin \| Musizin \| Inhibitor \| inhibit \| GLUT \| COX \| AMPK \| AMP-activated protein kinase
Inhibitors Related	Gum arabic \| Kojic acid \| Hydroxychloroquine \| Metronidazole \| Avermectin B1a \| 2-Amino-2-methyl-1-propanol \| Doxycycline \| Fenpyroximate \| Magnesium acetate tetrahydrate \| Methylene Blue trihydrate \| Trometamol \| Chitosan oligosaccharide
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