| Name | Nerol |
| Description | Nerol (Neryl alcohol) is a monoterpene found in many essential oils, such as lemon balm and hop.Nerol can lessened the severity of ouabain-triggered arrhythmias in mammalian heart. |
| Animal Research | Guinea pigs were sacrificed by decapitation and hearts were removed and isolated left atrium mounted vertically in an organ baths containing Tyrode's solution of the following composition (mM): NaCl 120, KCl 2.7, MgCl2 0.9, NaHCO3 11.9, CaCl2 1.37, glucose 5.5, NaH2PO4 0.4, pH 7.4. The atria preparations were subsequently connected to Grass FI'-03 force displacement transducers to record changes in atrial contractile force. Each muscle was stretched to the length at which contractile force was maximal (1.0 gf). The atria were electrically paced at 1 Hz with pulses of 1.5 ms duration and stimulated by 70 V pulses. All preparations were allowed to equilibrate for 30 min until complete mechanical stabilization had been achieved. Nerol ( 97%) was freshly solubilized in 0.5% DMSO and cumulatively added to bath chambers. After each observation, muscles were washed several times and allowed to recover for 30 minutes until their mechanical function completely returned to control values. DMSO at this concentration did not show any significant effect on the variables measured (data not shown, n = 5). |
| In vivo | Nerol primarily by reducing Ca2+ influx through L-type Ca2+ channel blockade lessened the severity of ouabain-triggered arrhythmias in mammalian heart. |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 45 mg/mL (291.73 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (12.97 mM), Sonication is recommended.
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| Keywords | ROS | ReactiveOxygenSpecies | Reactive Oxygen Species | Nerol | NEL | MitochondrialMetabolism | Mitochondrial Metabolism | mitochondrial | Inhibitor | inhibit | Fungal | EndogenousMetabolite | Endogenous Metabolite | dysfunction | Calcium | Apoptosis | Antifungal |
| Inhibitors Related | Sucrose | Calcium Propionate | Aceglutamide | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Benzyl propionate | Ethyl linoleate | Formamide | Glycerol | Thymidine | Gluconate Calcium |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Anti-Fungal Compound Library | Miao medicine Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Bitter Compound library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Flavor Natural Product library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ancient Chinese Classical Formulas Compound Library |
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