| Name | NFAT Transcription Factor Regulator-1 |
| Description | NFAT Transcription Factor Regulator-1 is a synthesis inhibitor of IL-2 with an IC50 of 182 nM. |
| In vitro | NFAT Transcription Factor Regulator-1 inhibits IL-2 synthesis(IC50 of 182 nM). NFAT Transcription Factor Regulator-1 inhibits human and rat PBMC proliferation with IC50s of 82 and 146 nM, respectively. NFAT Transcription Factor Regulator-1 is able to inhibit IL-4 and IL-5 production in human T-cell lines with similar potency to its effects on IL-2 release. |
| In vivo | NFAT Transcription Factor Regulator-1 demonstrates an inhibitory potency on T-cell IL-2 production that is approximately 10 times greater than cyclosporine, requiring doses of 3.0 mg/kg and 30 mg/kg, respectively, for comparable effects. In vivo studies in monkeys further reveal the potential of NFAT Transcription Factor Regulator-1 to block T-cell cytokine production effectively, suggesting its viability as a transplantation aid comparable to cyclosporine[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (120.11 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (12.01 mM), Sonication is recommended.
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| Keywords | NFAT Transcription Factor Regulator-1 | NFAT Transcription Factor Regulator1 | NFAT Transcription Factor Regulator 1 | ILReceptor | IL-2 synthesis | IL-2 | IL Receptor |
| Inhibitors Related | Kaolin | Undecane | Fluorene | Ethyl palmitate | Rhamnose monohydrate | Isostearic acid | D(+)-Raffinose pentahydrate | Hydroxypropyl Cellulose | 1,8-Cineole | Tributyrin | Gluconate Calcium | Magnesium sulfate |
| Related Compound Libraries | Bioactive Compound Library | Cytokine Inhibitor Library | Inhibitor Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |