| Name | Nicotinamide N-oxide |
| Description | Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase. |
| In vitro | Nicotinamide, a vitamin B3 variant, serves as a precursor to nicotinamide adenine dinucleotide, crucial for oxidative phosphorylation and dehydrogenase cofactor roles. It undergoes metabolism via two pathways: initial methylation by nicotinamide N-methyltransferase, followed by aldehyde oxidase oxidation, and direct oxidation to nicotinamide N-oxide. Studies have introduced a range of nicotinamide N-oxides as innovative, effective CXCR2 receptor antagonists. Specifically, Compound 1 effectively inhibits neutrophil chemotaxis (IC50=10 nM), whereas Compound 2 selectively blocks IL-8 binding (IC50=110 nM) and also significantly hampers neutrophil chemotaxis (IC50=170 nM). |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 3.85 mg/mL (27.87 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (7.24 mM), Sonication is recommended.
H2O : Limited solubility
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| Keywords | Nicotinamide N-oxide | Nicotinamide Noxide | Nicotinamide N oxide | Nicotinamide | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | DrugMetabolite | Drug Metabolite | CXCR | CXC chemokine receptors | c-Myc | cMyc |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Gut Microbial Metabolite Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | GPCR Compound Library | Food as Medicine Compound Library |
United States
