Nifuratel
Modify Date: 2024-01-02 11:16:35
 Nifuratel structure | Common Name | Nifuratel |
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| CAS Number | 4936-47-4 | Molecular Weight | 285.276 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 423.6±53.0 °C at 760 mmHg |
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| Molecular Formula | C10H11N3O5S | Melting Point | 176-178°C |
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| MSDS | N/A | Flash Point | 210.0±30.9 °C |
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Use of Nifuratel
Nifuratel(NF 113, SAP 113) is a broad antibacterial spectrum agent, which is used as an antibacterial, antifungal, and antiprotozoal (Trichomonas).IC50 Value: 0.125-1 μg/mL(MIC, A. vaginae) [1]Target: Antibacterial; Antiprotozoal in vitro: In vitro, nifuratel is able to inhibit the growth of A. vaginae, with a MIC range of 0.125-1 μg/mL; it is active against G. vaginalis and does not affect lactobacilli [1].in vivo: Patients were randomized to receive a 2-week course of bismuth subcitrate (8 mg/kg/day, q.d.s.), amoxicillin (50 mg/kg/day, q.d.s.), with either nifuratel (15 mg/kg/day, q.d.s.) or furazolidone (10 mg/kg/day, q.d.s.), plus omeprazole (0.5 mg/kg, once daily) [2].Toxicity: There were no serious adverse reactions and were no withdrawals due to any side-effects. All of side-effects were self-limiting (dark stools, urine discoloration, blackening of the tongue, and others) [3].Clinical trial: N/A |
Names
| Name | Nifuratel |
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| Synonym | More Synonyms |
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Nifuratel Biological Activity
| Description | Nifuratel(NF 113, SAP 113) is a broad antibacterial spectrum agent, which is used as an antibacterial, antifungal, and antiprotozoal (Trichomonas).IC50 Value: 0.125-1 μg/mL(MIC, A. vaginae) [1]Target: Antibacterial; Antiprotozoal in vitro: In vitro, nifuratel is able to inhibit the growth of A. vaginae, with a MIC range of 0.125-1 μg/mL; it is active against G. vaginalis and does not affect lactobacilli [1].in vivo: Patients were randomized to receive a 2-week course of bismuth subcitrate (8 mg/kg/day, q.d.s.), amoxicillin (50 mg/kg/day, q.d.s.), with either nifuratel (15 mg/kg/day, q.d.s.) or furazolidone (10 mg/kg/day, q.d.s.), plus omeprazole (0.5 mg/kg, once daily) [2].Toxicity: There were no serious adverse reactions and were no withdrawals due to any side-effects. All of side-effects were self-limiting (dark stools, urine discoloration, blackening of the tongue, and others) [3].Clinical trial: N/A |
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| Related Catalog | Signaling Pathways >> Anti-infection >> Bacterial Signaling Pathways >> Anti-infection >> Parasite Natural Products >> Alkaloid Research Areas >> Infection |
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| References | [1]. Polatti F. Bacterial vaginosis, Atopobium vaginae and nifuratel. Curr Clin Pharmacol. 2012 Feb 1;7(1):36-40. [2]. Nijevitch AA, et al. Helicobacter pylori eradication in childhood after failure of initial treatment: advantage of quadruple therapy withnifuratel to furazolidone. Aliment Pharmacol Ther. 2005 Nov 1;22(9):881-7. [3]. Nijevitch AA, et al. Nifuratel-containing initial anti-Helicobacter pylori triple therapy in children. Helicobacter. 2007 Apr;12(2):132-5. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 423.6±53.0 °C at 760 mmHg |
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| Melting Point | 176-178°C |
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| Molecular Formula | C10H11N3O5S |
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| Molecular Weight | 285.276 |
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| Flash Point | 210.0±30.9 °C |
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| Exact Mass | 285.041931 |
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| PSA | 126.16000 |
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| LogP | 0.27 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.666 |
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| Storage condition | -20°C Freezer |
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Toxicological Information
CHEMICAL IDENTIFICATIONCAS REGISTRY NUMBER : 4936-47-4
MOLECULAR FORMULA : C10-H11-N3-O5-S
HEALTH HAZARD DATAACUTE TOXICITY DATASPECIES OBSERVED : Rodent - rat
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >4500 mg/kg
MUTATION DATADOSE/DURATION : 50 ng/plate
REFERENCE : MIGIA6 Minerva Ginecologia. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1949- Volume(issue)/page/year: 31,263,1979
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
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| Safety Phrases | S26-S36-S37/39 |
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| WGK Germany | 3 |
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