| Name | Nilvadipine |
| Description | Nilvadipine (FK235), a calcium channel blocker (CCB), is utilized for treatment of hypertension. |
| In vitro | In RCS rats' retinas, Nilvadipine significantly increased the expression of rhodopsin kinase and αA-crystallin, while it decreased the expression of caspase-1 and caspase-2. It also entirely inhibited arterial vasoactivity induced by Abeta in rat aortas and human brains. Furthermore, Nilvadipine (0.4 mg/kg i.v. and 2 mg/kg p.o.) was able to reduce paw edema induced by localized ischemia in mice. |
| In vivo | In perfused hydronephrotic kidneys, Nilvadipine effectively dilates both afferent and efferent arterioles, enhancing renal blood flow. Moreover, in rat aortic smooth muscle cells (IC50=0.1 nM), Nilvadipine inhibits the chemotactic responses to interleukin-1, leukotriene B4, and platelet-derived growth factor. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 19.3 mg/mL (50.08 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.5 mg/mL (6.49 mM), Sonication is recommended.
DMSO : 55 mg/mL (142.72 mM), Sonication is recommended.
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| Keywords | Nilvadipine | Inhibitor | inhibit | FR-34235 | FR 34235 | FK-235 | FK 235 | CalciumChannel | Calcium Channel | Ca2+ channels | Ca channels | ARC-029 | ARC 029 |
| Inhibitors Related | Quadrol | Tricaine methanesulfonate | Nisoldipine | 2,4,6-Tri-tert-butylphenol | Chlorocresol | L-Ascorbic acid | L-Phenylalanine | L-Ascorbic acid sodium salt | 1-Octanol | 2-Nitrobenzoic acid | Magnesium Chloride Hexahydrate | Magnesium sulfate |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Neuroprotective Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |
United States
