| Name | Nitazoxanide |
| Description | Nitazoxanide (NSC-697855) is a synthetic benzamide with antiprotozoal activity. Nitazoxanide exerts its antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron transfer reaction. |
| In vitro | In a model of abiotic piglet diarrhea, oral administration of Nitazoxanide (250 mg/kg/day) was effective in reducing the survival of parasites within the host organism. |
| In vivo | Nitazoxanide effectively inhibits the growth of a broad spectrum of protozoans and helminths, such as Blastocystis hominis, Entamoeba histolytica, and Trichomonas vaginalis, without exhibiting cytotoxicity. It demonstrates inhibitory concentrations against E. histolytica (IC50=0.017 mg/mL, IC90=0.776 mg/mL), G. intestinalis (IC50=0.004 mg/mL, IC90=0.067 mg/mL), and T. vaginalis (IC50= 0.034 mg/mL, IC90=2.046 mg/mL). |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.5 mg/mL (8.14 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 247.5 mg/mL (805.45 mM), Sonication is recommended.
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| Keywords | trophozoite | protozoa | PFOR | parasitic | Parasite | NTZ | NSC-697855 | NSC697855 | Nitazoxanide | JEV | Inhibitor | inhibit | InfluenzaVirus | Influenza Virus | helminths | Giardia lamblia | gastroenteritis ,virus | enteric | bacteria infecting | Autophagy | anthelmintic |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Guanidine hydrochloride | Hydroxychloroquine | Metronidazole | 2-Amino-2-methyl-1-propanol | Doxycycline | Fenpyroximate | Paeonol | Naringin | Alginic acid |
| Related Compound Libraries | Anti-Parasitic Compound Library | Failed Clinical Trials Compound Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
