| Name | Nizatidine |
| Description | Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity. |
| In vitro | In rats, Nizatidine exhibits its maximum inhibitory effect on gastric acid secretion one hour after administration, with an EC50 value of 1.383 μMol/kg. Intravenous administration of Nizatidine (0.3-3 mg/kg) not only enhances gastrointestinal motility but also suppresses gastric acid secretion, achieving 50% of the maximal effect at a dose of 2.94 mg/kg and 90% at 19.6 mg/kg for rats. |
| In vivo | Nizatidine is a reversible, non-competitive inhibitor of acetylcholinesterase (IC50=6.7 μM, Ki=7.4 μM) and a selective antagonist of the histamine H2 receptor, effectively inhibiting gastric acid secretion (IC50=0.9 nM). |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 60 mg/mL (181.02 mM), Sonication is recommended.
H2O : 26 mg/mL (78.44 mM), Sonication is recommended.
Ethanol : 15 mg/mL (45.25 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (9.96 mM), Sonication is recommended.
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| Keywords | stomach | Nizatidine | intestines ulcers | Inhibitor | inhibit | HistamineReceptor | Histamine Receptor | hcc | H2 receptor | GERD | gastroesophageal reflux disease | erosive esophagitis | cancer | acid | AChE |
| Inhibitors Related | Undecane | Meclizine dihydrochloride | Ethyl (triphenylphosphoranylidene) acetate | Famotidine | Diethyltoluamide | Sodium butanoate | Propoxur | Dimethyl sulfoxide | Coumaran | Alginic acid | Methyl tridecanoate | Trimethylammonium chloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
United States
