| Name | Norathyriol |
| Description | Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability. |
| In vitro | Normal or IR L6 myotubes were incubated with Norathyriol (2.5 - 10 μM, 0.625 - 2.5 μM), mangiferin (10 - 40 μM, 2.5 - 10 μM) or rosiglitazone (20 μM) and/or 0.05 nM insulin for 24 h, respectively. The glucose consumption was assessed using the glucose oxidase method. Immunoblotting was performed to detect protein kinase B (PKB/Akt) and AMP-activated protein kinase (AMPK) phosphorylation in L6 myotubes cells. Norathyriol and mangiferin treatment alone increased the glucose consumption 61.9 and 56.3%, respectively, in L6 myotubes and made additional increasing with 0.05 nM insulin. In IR L6 myotubes, Norathyriol treatment made increasing with or without insulin, mangiferin treatment also made increasing but only when co-treated with insulin. Immunoblotting results showed that Norathyriol and mangiferin produced an increase of 1.9 - and 1.8-fold in the phosphorylation levels of the AMPK, but not in Akt[1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 145 mg/mL (557.26 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.69 mM), Sonication is recommended.
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| Keywords | α-glucosidase | RNASynthesis | RNA Synthesis | PPAR | Peroxisome proliferator-activated receptors | Norathyriol | Natural | metabolite | Mangiferitin | Mangifera | Inhibitor | inhibit | Glucosidase | DNASynthesis | DNA Synthesis | AP-1 | Antioxidant | antimicrobial | anti-inflammatory | anticancer | anti-bacterial | AMPK | Akt |
| Inhibitors Related | Aceglutamide | 5-Fluorouracil | Hyaluronic acid | Guanidine hydrochloride | Daidzein | 1,4-Naphthoquinone | Adenine | Ethyl linoleate | Magnesium acetate tetrahydrate | Carbazole | Thymidine | Chitosan oligosaccharide |
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