| Name | Novobiocin |
| Description | Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on gyrase and Hsp90. Novobiocin has anti-positive activity and can be used to study highly resistant pneumococcal infections. |
| In vitro | Novobiocin (1 mM) competitively hinders the binding of ATP to gyrase B, disrupting nucleotide binding, and impairs the interaction between the co-chaperones Hsc70 and p23 with Hsp90.[1]
Novobiocin (200 µM; 24 h) results in the inhibition of the repair rate of DNA interstrand cross-links induced by both cisplatin (cis-DDP) and BCNU. This is accompanied by a corresponding reduction in the clonogenic survival of human glioblastoma multiforme cells.[2]
Novobiocin (0.3 mM; 48 hours) triggers caspase-3/7 enzyme-dependent apoptosis assays, resulting in an approximate three- to fivefold increase in the number of apoptotic cells in K562, HL60, and Mutz-2.[5] |
| In vivo | Novobiocin (25, 50, 100, 200 mg/kg; s.c.; 4 times at 1, 5, 24, and 48 h after infection; Adult female Swiss mice (30g) with sepsis induced by the penicillin-susceptible strain (AR33118)) exhibits anti-infection activity in mice infected with amoxicillin-resistant Streptococcus pneumoniae.[3] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 237.5 mg/mL (387.68 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 5 mg/mL (8.16 mM), Sonication is recommended.
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| Keywords | VirusProtease | Virus Protease | Orthopoxvirus | Novobiocin | HSP90 | DNAgyrase | DNA gyrase | Bacterial | Apoptosis | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Aceglutamide | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Sulfamethoxazole sodium | Terbinafine hydrochloride | Formamide | Thymidine | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Natural Product Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
United States
