| Name | NS9283 |
| Description | NS9283, a positive allosteric modulator selective for the α4β2 form, reduces ethanol consumption. |
| In vitro | NS9283 increased the potency of varenicline to activate and desensitize α4β2?nAChRs in vitro without affecting other known targets of varenicline[2]. |
| In vivo | In male and female C57BL/6J mice, NS9283 (10 mg/kg) reduced ethanol intake in a two-bottle choice, intermittent drinking procedure without affecting saccharin intake, ethanol-induced incoordination or ethanol-induced loss of the righting reflex. Subthreshold doses of NS9283 (2.5 mg/kg) plus varenicline (0.1 mg/kg) synergistically reduced ethanol intake in both sexes. Finally, despite having no aversive valence of its own, NS9283 enhanced ethanol-conditioned place aversion[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 3.06 mg/mL (12.33 mM), Sonication is recommended.
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| Keywords | α4β2 nAChR | NS9283 | Nicotinic acetylcholine receptors | nAChR | Inhibitor | inhibit |
| Inhibitors Related | Adiphenine hydrochloride | Levamisole hydrochloride | Ethyl (triphenylphosphoranylidene) acetate | Urethane | Hexamethonium Bromide | Ribavirin | Adenine | Mitotane | Choline chloride | Propoxur | N,N-Dicyclohexylcarbodiimide | Arecoline |
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