| Name | NSC 228155 |
| Description | NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulating EGFR tyrosine phosphorylation. |
| Cell Research | MDA MB468 cells serum-starved overnight are pre-incubated (or not) with 10?μM AG1478 or 2?μM PD 153035 for 90?min and then, where indicated, incubated with 100?μM NSC 228155 or CN 009543V or 150?ng/ml EGF or vehicle (0.2% DMSO) for 15?min. Proteins are blotted to nitrocellulose membrane and analyzed with biotinylated anti-pTyr P100, anti-pEGFR Y1068 and anti-EGFR (epitope in cytoplasmic region) antibodies. (Only for Reference) |
| In vitro | NSC 228155 promotes transactivation of several RTKs, including ErbB2 and ErbB3, Insulin R and IGF-1 R receptors in the cells. It stimulates dimerization of sEGFR domain II[1]. NSC 228155 can rapidly move across cell membranes and disperse within both cytoplasmic and nuclear compartments. It rapidly generates hydrogen peroxide within cells[2]. NSC 228155 is also a potent inhibitor of KIX-KID interaction(IC50 = 0.36 μM), but it is not particularly selective against CREB-mediated gene transcription in HEK 293T cells[3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 7.34 mg/mL (25.29 mM), Sonication is recommended.
10% DMSO+90% Corn Oil : 1 mg/mL (3.45 mM), Sonication is recommended.
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| Keywords | RNASynthesis | RNA Synthesis | NSC-228155 | NSC 228155 | KIX-KID interaction | Inhibitor | inhibit | HistoneAcetyltransferase | Histone Acetyltransferase | HER1 | HATs | HAT | ErbB-1 | EpigeneticReaderDomain | Epigenetic Reader Domain | Epidermal growth factor receptor | EGFR | DNASynthesis | DNA Synthesis |
| Inhibitors Related | 5-Fluorouracil | Acetaminophen | Guanidine hydrochloride | Hexane-1,6-diol | Manganese chloride (tetrahydrate) | 1,4-Naphthoquinone | Adenine | Curcumin | Carbazole | Thymidine | Gefitinib | Usnic Acid |
| Related Compound Libraries | Anti-Colorectal Cancer Compound Library | Reprogramming Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Ovarian Cancer Compound Library | JAK-STAT Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Hypertension Compound Library |
United States
