| Name | NSC781406 |
| Description | NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα). |
| In vitro | NSC781406 shows reasonable liver microsome stability. NSC781406 displays effective PI3K inhibition (PI3Kα IC50=2.0 nM) that translates into BEL-7404 cells proliferation inhibition (IC50=20 nM) and it also demonstrates cytotoxic activities against leukemia, non-small cell, lung cancer, colon cancer, central nervous system cancer, melanoma, ovarian cancer, renal cancer, prostate cancer, and breast cancer. It is effective against 60 cancer cell lines with a mean GI50 value of 65 nM and with a GI50 value of less than 10 nM against four cancer cell lines. |
| In vivo | NSC781406 is well tolerated at 30 mg/kg, with no observed mortality or significant reduction of body weight. NSC781406(30 mg/kg) treatment, causes statistically significant antitumor activity, in the xenograft models. It has a mean reduction in the relative tumor volume ratio of 52%. Sorafenib shows an inhibition ratio of 44% at 50 mg/kg . |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 150 mg/mL (238.98 mM), Sonication is recommended.
10% DMSO+90% Corn Oil : 4 mg/mL (6.37 mM), Sonication is recommended.
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| Keywords | PI3Kδ | PI3Kγ | PI3Kβ | PI3Kα | PI3K | Phosphoinositide 3-kinase | NSC-781406 | NSC781406 | NSC 781406 | mTOR | Mammalian target of Rapamycin | Inhibitor | inhibit |
| Inhibitors Related | Musk ketone | Stearamide | L-Leucine | Myricetin | Creatine monohydrate | Hyaluronic acid | L-Proline | Isoprenaline hydrochloride | Metformin | Methyl eugenol | Quercetin | Dihydromyricetin |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | Bioactive Compound Library | Antidepressant Compound Library | Kinase Inhibitor Library | Glutamine Metabolism Compound Library | Inhibitor Library | Stem Cell Differentiation Compound Library | Anti-Fibrosis Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Oxidation-Reduction Compound Library |
United States
