| Name | NUCC-390 |
| Description | NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100. This compound facilitates nerve functional recovery following neurodegeneration in vivo. |
| In vitro | NUCC-390 (10 μM) elicits a strong (Ca)i response, which can be blocked by the potent and selective CXCR4 antagonist AMD3100. Pre-treatment with NUCC-390 (10 μM; 30 mins) increases pERK levels, stimulating signaling activity downstream of CXCR4 receptors. NUCC-390 (10 μM; 2 hours) induces CXCR4 receptor internalization, while non-treated cells show diffuse CXCR4-YFP expression in the cytosol and clear membrane expression in HEK cells[1]. Additionally, NUCC-390 (0-1.25 μM; 24 hours) enhances axonal growth in cultured cerebellar granule neurons (CGNs) via CXCR4[2]. |
| In vivo | NUCC-390 (hind limb injection; 3.2 mg/kg; twice daily; 3 days) enhances functional and anatomical recovery of the neuromuscular junction (NMJ) after acute nerve terminal damage by α-LTx in CD-1 mice[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pure form: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 60 mg/mL (151.69 mM), Sonication is recommended.
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| Keywords | NUCC-390 | NUCC390 | NUCC 390 | CXCR4 |
| Inhibitors Related | AZD8309 | rac-NBI-74330 | Delmetacin | Tannic acid | Artemotil | CXCR2-IN-1 | Soquelitinib | Plerixafor octahydrochloride | Tanimilast | 3-Indoleglyoxylic acid | Nicotinamide N-oxide | CXCL-CXCR1/2-IN-1 |
| Related Compound Libraries | Bioactive Compound Library | Cytokine Inhibitor Library | Membrane Protein-targeted Compound Library | Hematonosis Compound Library | Autophagy Compound Library | Chemokine Inhibitor Library | Angiogenesis related Compound Library | Immuno-Oncology Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library |
United States
