O-(2-(vinyloxy)ethyl)hydroxylamine NEW

Product name: O-(2-(vinyloxy)ethyl)hydroxylamine

CAS Number: 391212-29-6

Molecular Weight: 103.12

Molecular Formula:C4H9NO2

Chemical & Physical Properties

Uses and preparation of O-(2-(vinyloxy)ethyl)hydroxylamine:

 1-[2-(aminooxy)ethoxy]ethylene is an intermediate in organic synthesis and pharmaceutical intermediates, which can be used in laboratory research and development processes and chemical and pharmaceutical synthesis processes.
1-[2-(aminooxy)ethoxy]ethylene is prepared as follows: 2-(2-(vinyloxy)ethoxy)isoindoline-1,3- Dione was added to a THF (450 mL) solution of 2-(vinyloxy)ethanol (20.4 mL, 227 mmol), triphenylphosphine (59.5 g, 227 mmol) and N-hydroxyphthalimide (37.0 g, 227 mmol) in a THF (450 mL) atmosphere, approximately 227 mmol at 0 °C. After stirring at room temperature for 16 h, the reaction mixture is vacuum-concentrated. The residue was filtered, washed with chloroform, and the filtrate was vacuum-concentrated. The residue was purified by SiO2 column chromatography (hexane∶EtOAc=2∶1) to obtain 2-(2-(vinyloxy)ethoxy)isoindolin-1,3-dione (32.5g, 61.4%), which was a yellow solid. An aqueous solution of methylhydrazine (15.8 mL, 137 mmol) was added dropwise to the solution of 2-(2-(vinyloxy)ethoxy)isoindolin-1,3-dione (32.0 g, 137 mmol) in DCM (96.0 mL). Room temperature. After stirring for 1 h at room temperature, the resulting suspension is diluted with ether and filtered. The filtrate is vacuum-concentrated. The residue was purified by column chromatography on SiO2 (hexane:EtOAc=3:2 to 1:1) to obtain O-(2-(vinyloxy)ethyl)-hydroxylamine (10.7g, 76%) in the form of yellow oil.

Monitoring Methods:
GBZ/T 160.1 ~ GBZ/T 160.81-2004 Determination of toxic substances in the workplace air (series of standards), EN 14042 Workplace air A guide to procedures used to assess exposure to chemical or biological agents

Engineering Controls:
It is recommended that the workplace be separated from other workplaces.
Closed operation to prevent leakage.
Ventilation is strengthened.
Set up automatic alarm devices and accident ventilation facilities.
Set up emergency evacuation channels and necessary evacuation areas.
Set red area warning lines, warning signs and Chinese warning instructions, and set up a communication alarm system.
Safety showers and eyewash equipment are available.

Personal Protective Equipment:
Respiratory protection: When the concentration in the air exceeds the standard, wear a filtering gas mask (half mask). In the event of an emergency or evacuation, an air-carrying respirator should be worn.
Hand protection: Wear rubber oil-resistant gloves.
Eye protection: Wear chemical-safe eye protection.
Skin and body protection: Wear anti-poison penetrating coveralls.

Shipping Notes:
Transport vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment.
It is strictly forbidden to mix with oxidants, edible chemicals, etc.
The exhaust pipe of the vehicle from which the item is shipped must be equipped with a fire arresting device.
There should be a grounding chain when using a tank (tank) truck for transportation, and a hole partition can be set in the tank to reduce the static electricity generated by vibration.
It is forbidden to use mechanical equipment and tools that are prone to sparks for loading and unloading.
In summer, it is best to transport it in the morning and evening.
During transportation, it should be protected from exposure to sun, rain and high temperature.
During the stopover, it should be kept away from fire, heat sources, and high temperature areas.
When transporting by road, it is necessary to drive according to the prescribed route and do not stop in residential areas and densely populated areas.
It is forbidden to slip when transporting by rail.
It is strictly forbidden to transport in bulk by wooden ship or cement ship.
Hazard signs and announcements shall be posted on the means of transport in accordance with the relevant transport requirements.