| Name | Okanin |
| Description | Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect. |
| In vitro | Activity-guided fractionation of the EtOH extract of flowers of Bidens bipinnata L. have been furnished five flavonoids, sulfuretin(1), butein(2), 7,8,3?2,4?2-tetrahydroxyflavanone(3), maritimetin(4) and Okanin(5). All of the compounds showed significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect. The evaluation for protective effect of isolated compounds against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells was conducted. Compounds 1, 3, 4 and 5 showed significant protective effects with the EC50 values of 36.1±0.9, 23.3±0.7, 41.0±1.0 and 29.8±1.1 μM, respectively[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 135 mg/mL (468.34 mM), Sonication is recommended. 10% DMSO+90% Saline : 2 mg/mL (6.94 mM), Sonication is recommended.
|
| Keywords | Toll-like Receptor (TLR) | TLR4 | TLR | Okanin | Nuclear factor-κB | Nuclear factor-kappaB | Nrf2 | NO Synthase | NF-κB | NFκB | NF-kB | NFkB | Inhibitor | inhibit |
| Inhibitors Related | Sodium propionate | Ethyl palmitate | Kojic acid | Uridine | Hydroxychloroquine | Fumaric acid | Benzyl alcohol | 1,4-Naphthoquinone | Glucosamine | Ethyl linoleate | N,N-Dimethylacetamide | Magnesium sulfate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |