| Name | ONO-5334 |
| Description | ONO-5334 is a selective, orally active and potent histone K inhibitor with anti-SAR-COV-2 and anti-bone resorption activity for the study of osteoporosis. |
| In vitro | ONO-5334 inhibits human cathepsin S, L, and B, and porcine calpain Ι and II (Ki: 0.83 nM, 1.7 nM, 32 nM, 82 nM, and 69 nM, respectively). ONO-5334 (0.1-1 μM; 24 hours) also inhibits human osteoclast-mediated bone resorption, effectively decreasing the osteoclast-mediated release of CTX from bone slices in a dose-dependent manner[1]. |
| In vivo | ONO-5334 (oral; 0.3-30 mg/kg; 7 consecutive days) at doses of 3 mg/kg or 30 mg/kg significantly reduced CTX (bone resorption marker) concentrations.ONO-5334 (oral; 0.12-15 mg/kg; single dose) dose-dependently reduced PTHrP-induced elevation of plasma calcium, with a significant effect at 15 mg/kg (86% reduction). It also reduced the PTHrP-induced increase in plasma CTX levels in TPTX rats by 90% at 15 mg/kg. On day 7, ONO-5334 (3 mg/kg and 30 mg/kg) reduced serum CTX concentrations by 62% and 79%, respectively[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 30 mg/mL (68.4 mM), Sonication is recommended.
|
| Keywords | SARS-CoV-2 | SARSCoV | rat cathepsin K | rabbit cathepsin K | ONO-5334 | ONO5334 | ONO 5334 | human cathepsin K | CysteineProtease | Cysteine Protease | Cathepsin K |
| Inhibitors Related | Papain | EIDD-1931 | Remdesivir | Molnupiravir | Silymarin | Umifenovir hydrochloride | Hydroxychloroquine | Ritonavir | Chloroquine phosphate | Dexamethasone acetate | α-Cyclodextrin | Dexamethasone |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Protease Inhibitor Library | Multi-Target Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | Orally Active Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |
United States
