| Name | ONO-7475 |
| Description | ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase |
| Cell Research | Cell Line:High AXL-expressing cell: PC-9,HCC4011,H1975, PC-9KGR cells. Low AXL-expressing cell: HCC827, HCC4006, and H3255 cells. Concentration:0.0001 μM; 0.001 μM; 0.01 μM; 0.1 μM; 1 μM. Incubation Time:72 hours[1]. |
| In vitro | ONO-7475 sensitized AXL-overexpressing?EGFR-mutant NSCLC cells to the EGFR-TKIs osimertinib and dacomitinib. In addition, ONO-7475 suppressed the emergence and maintenance of EGFR-TKI-tolerant cells[2]. |
| In vivo | Mice fed a diet containing ONO-7475 exhibited significantly longer survival and, interestingly, blocked leukemia cell infiltration in the liver. In summary, ONO-7475 effectively kills acute myeloid leukemia cells?in vitro?and?in vivo?by mechanisms that involve disruption of diverse survival and proliferation pathways[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (177.76 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 1 mg/mL (1.78 mM), Sonication is recommended.
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| Keywords | Tyro3 | tumor | Tropomyosin related kinase receptor | Trkreceptor | Trk receptor | tolerant | TKI | TAMReceptor | TAM Receptor | solid | ONO-7475 | ONO7475 | ONO 7475 | NSCLC | mutunt | metastatic | Mer | lung | leukemia | Inhibitor | inhibit | EGFR | cancer | Axl | advanced | acute |
| Inhibitors Related | Bemcentinib | Gilteritinib | Amitriptyline | Larotrectinib sulfate | SP600125 | 7,8-Dihydroxyflavone | Amitriptyline hydrochloride | Tepotinib | GW 441756 | Cabozantinib S-malate | ALE-0540 | NSI-189 Phosphate |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |