| Name | OPHIOPOGONIN D |
| Description | Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation. |
| In vitro | OPHIOPOGONIN D(OP-D) significantly inhibited Ang II induced NF-κB nuclear translocation, IκBα down-regulation and activation of pro-inflammatory cytokines (TNF-α, IL-6 and VCAM-1) by increasing the expression of CYP2J2/EETs and PPARα in HUVECs.?Furthermore, treatment with exogenous 11,12-EET attenuated endothelial inflammation induced by Ang II as evidenced by inhibited NF-κB nuclear translocation, increased IκBα expression and decreased inflammation factor level.?Finally, the activation of NF-κB nuclear translocation induced by Ang II was also markedly suppressed by fenofibrate.?Co-incubation with 6-(2-proparglyloxyphenyl) hexanoic acid (PPOH) and PPARα inhibitor GW6471 before drug treatment abolished the endothelium protective effects of OP-D.?Suggest that OP-D has the endothelial protective effect through activation of CYP2J and increasing EETs, and PPARα involves in this process. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 2 mg/mL (2.34 mM), Sonication is recommended.
DMSO : 30 mg/mL (35.09 mM), Sonication is recommended.
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| Keywords | PPAR | Peroxisome proliferator-activated receptors | OPHIOPOGONIN D | Nuclear factor-κB | Nuclear factor-kappaB | NF-κB | NFκB | NF-kB | NFkB | Inhibitor | inhibit | CalciumChannel | Calcium Channel | Ca2+ channels | Ca channels | angiotensin II receptor |
| Inhibitors Related | Ethoxyquin | Kaolin | Allopurinol | 2,4,6-Tri-tert-butylphenol | Urea | Daidzein | Ethyl linoleate | Magnesium acetate tetrahydrate | Gluconate Calcium | Dimethyl phthalate | Diisononyl phthalate | Magnesium Chloride Hexahydrate |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Saccharide and Glycoside Natural Product Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ion Channel Targeted Library | Food as Medicine Compound Library |
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