PRODUCT INFORMATION
| Common Name | Oseltamivir |
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| CAS Number | 196618-13-0 | Molecular Weight | 312.40 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 445.4±55.0 °C at 760 mmHg |
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| Molecular Formula | C16H28N2O4 | Melting Point | 109 °C |
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| MSDS | N/A | Flash Point | 223.2±31.5 °C |
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Use of Oseltamivir Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively[1]. |
Names
| Name | oseltamivir |
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| Synonym | More Synonyms |
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Oseltamivir Biological Activity
| Description | Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively[1]. |
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| Related Catalog | Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection |
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| References | [1]. O Ferraris, et al. Sensitivity of Influenza Viruses to Zanamivir and Oseltamivir: A Study Performed on Viruses Circulating in France Prior to the Introduction of Neuraminidase Inhibitors in Clinical Practice. Antiviral Res. 2005 Oct;68(1):43-8. [2]. Smee DF, et al. Activities of JNJ63623872 and oseltamivir against influenza A H1N1pdm and H3N2 virus infections in mice. Antiviral Res. 2016 Dec;136:45-50. [3]. Ilyushina NA, et al. Amantadine-oseltamivir combination therapy for H5N1 influenza virus infection in mice. Antivir Ther. 2007;12(3):363-70. [4]. Ilyushina NA, et al. Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice. Antimicrob Agents Chemother. 2008 Nov;52(11):3889-97. [5]. Smee DF, et al. Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice. Antiviral Res. 2010 Oct;88(1):38-44. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 445.4±55.0 °C at 760 mmHg |
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| Melting Point | 109 °C |
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| Molecular Formula | C16H28N2O4 |
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| Molecular Weight | 312.40 |
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| Flash Point | 223.2±31.5 °C |
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| Exact Mass | 312.204895 |
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| PSA | 90.65000 |
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| LogP | 2.52 |
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| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
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| Index of Refraction | 1.529 |
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Precursor & DownStream
| Precursor 6 | Previous 1/2 Next |
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CAS#:312904-18-0 ethyl (3R,4R,5S...
CAS#:204255-06-1 5-Azido Oseltamivir
CAS#:1041262-68-3 ethyl (3R,4R,5S...
CAS#:367252-68-4 oseltamivir
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| DownStream 1 |
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Synonyms
| OSELTAMIVIR |
| (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester |
| Oseltamivir (free base) |
| TaMvir |
| GOP-A-Flu |
| (3R,5S)-ethyl 4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate |
| TaMiflu-Free |
| TAMIFLU |
| (3R,4R,5S)-4-acetylamino-5-amino-3(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester |
| OSTELTAMIVIR |
| (3R,4R,5S)-5-amino-4-acetylamino-3-(1-ethyl-propoxy)-cyclohex-1-ene-carboxylic acid ethyl ester |
| GS 4104 |
| ethyl (3R,4R,5S)-5-aMino-4-acetaMido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate |
| [14C]-Oseltamivir |
| ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate |
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