Human OSMR beta Protein, His Tag (MALS verified)
Synonym
Oncostatin-M-specific receptor subunit beta, Interleukin-31 receptor subunit beta, IL-31 receptor subunit beta, IL-31R subunit beta, IL-31R-beta, IL-31RB, OSMR, OSMRB
Source
Human OSMR, His Tag (OSR-H52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 28 - Met 740 (Accession # Q99650-1).
Predicted N-terminus: Glu 28
Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 83.0 kDa. The protein migrates as 105-125 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
Background
Oncostatin-M-specific receptor subunit beta(OSMRB) alos know as Interleukin-31 receptor subunit beta (IL-31RB), is an alternative subunit (OSMRβ) for an OSM receptor complex (a heterodimer of gp130 and OSMRβ), that is activated by OSM but not by LIF. OSMR beta associates with the low affinity OSM·gp130 complex to form a high affinity heterodimeric receptor that is capable of transducing OSM-specific signaling events.
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