| Name | OSS_128167 |
| Description | OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM). |
| Cell Research | BxPC3 cells are stimulated with 100 μM OSS-128167 incubating 0, 2, 6, 18, 24 hours. |
| Kinase Assay | In supernatants from cells, which are incubated in OSS_128167 (100 μM) for 18 hours,TNF-a levels are measured . |
| In vitro | OSS-128167 increases H3K9 acetylation and GLUT-1 expression, and proves to be a selective compounds toward SIRT6. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.46 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 50 mg/mL (136.49 mM), Sonication is recommended. Ethanol : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | TNF-α | Sirtuin | SIRT6 | SIRT2 | SIRT1 | PPARα | OSS_128167 | Inhibitor | inhibit | immune | Hepatitis B virus | HBV | H3K9 | GLUT-1 | diabetes | deacetylase | chemosensitization | antiviral | anti-cancer | acetylation |
| Inhibitors Related | Doxorubicin hydrochloride | Famciclovir | Nicotinamide riboside malate | Lamivudine | Cetylpyridinium Chloride | Tenofovir Disoproxil Fumarate | Estradiol benzoate | Thiamine hydrochloride | Fisetin | (Tetrahydro-2H-pyran-4-yl)methanol | Nicotinamide | Tenofovir |
| Related Compound Libraries | DNA Damage & Repair Compound Library | Bioactive Compound Library | Chromatin Modification Compound Library | Glutamine Metabolism Compound Library | Anti-Viral Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Anti-Cancer Active Compound Library |