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ChemicalBook Product Catalog OT-82

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OT-82 NEW

$ 299.00 /2mg

Min. Order
Purity98.91%
Cas No1800487-55-1
Supply Ability10g
Update time2025-12-22

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

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Chemical Properties

Product Name	OT-82
CAS No	1800487-55-1
EC-No
Min. Order
Purity	98.91%
Supply Ability	10g
Release date	2025/12/22

Product Introduction

Bioactivity

Name	OT-82
Description	OT-82 is a potent, selective, and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT).
In vitro	METHODS: OT-82 (0.001-10 μM) was used to treat human cell lines derived from HP and non-HP cancers, and the IC50 values were determined. RESULTS: The average IC50 of OT-82 was significantly higher in non-HP cancer cells compared with HP cancer cells (13.03±2.94 nM vs 2.89±0.47 nM; p < 0.008). [1] METHODS: MV4-11 cells were treated with OT-82 (0.001-10 nM), and the changes in NAD were observed for 24 hours, and the changes in ATP were observed for 24 hours and 48 hours. RESULTS: OT-82 treatment resulted in a dose-dependent decrease in NAD and ATP concentrations in MV4-11 cells. OT-82 treatment of MV4-11 cells in vitro for 48 hours resulted in caspase-3 activation, an increase in the proportion of cells with sub-G1 DNA content, and mitochondrial membrane depolarization. OT-82 induced apoptosis and cell death by inhibiting NAMPT, leading to NAD and ATP depletion. [1]
In vivo	METHODS: OT-82 (25 or 50 mg/kg) was administered orally 6 days per week for 3 weeks. The therapeutic efficacy of OT-82 was tested in vivo using subcutaneous (SC) and systemic mouse xenograft models of HP malignancies. RESULTS: OT-82 caused a dose-dependent inhibition of SC growth of human AML-derived MV4-11 cells; the 25 mg/kg dose resulted in a 3-fold reduction in mean tumor volume at day 17 of treatment, while higher doses resulted in complete eradication of tumors within 10 days of treatment initiation. [1]
Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 80 mg/mL (188.47 mM), Sonication is recommended.
Keywords	OT-82 \| Nampt \| NAMPT
Inhibitors Related	GNE-617 \| Nampt-IN-5 \| LB-60-OF61 \| Nampt activator-2 \| SBI-797812 \| Nampt-IN-1 \| KPT9274 \| CHS-828 \| Nampt activator-1 \| (E)-Daporinad \| STF-118804 \| Daporinad hydrochloride

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