Pharmacodynamic oxytetracycline is a broad spectrum antibiotic, which has strong effects on gram-positive bacteria such as staphylococcus, hemolytic streptococcus, anthrax, Clostridium tetanus and Clostridium difficile. It is sensitive to gram-negative bacteria such as Escherichia coli, Salmonella, Brucella and Pasteurella. This product can also inhibit Rickettsia, chlamydia, mycoplasma, spirochaeta, actinomyces and some protozoa.
The pharmacokinetic oxytetracycline hydrochloride appeared in serum 5 minutes after intramuscular injection of pigs and reached its peak within 2 hours. The maintenance time of serum therapeutic concentration (>1g/ml) after intramuscular injection or intravenous injection of 10mg/kg was longer for intramuscular injection (18-19 hours) than for intravenous injection (8 hours). The horse was given intramuscular or intravenous injection of 5mg/kg at a mean 24-hour blood concentration of 1.52pg/ml for intravenous injection and 0.72ug/ml for intramuscular injection. The half-life is 15.7 hours for intravenous injection and 10.5 hours for intramuscular injection. After absorption, it is widely distributed in liver, kidney, lung and other tissues and body fluids, easily penetrating into pleural fluid, ascites, placenta and milk. It does not easily cross the blood-brain barrier. There is also a trace of infiltration in human rumen fluid, and can be deposited in bone, teeth and other tissues. It is mainly excreted in urine as a prototype. Part of it is concentrated in the liver bile, discharged into the intestine, and part of it is absorbed again, forming the hepato-intestinal circulation.
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