| Name | Oxytetracycline |
| Description | Oxytetracycline (Terramycin) is a TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions. |
| In vivo | Oxytetracycline (200 mg/kg for 15 days) results a significant elevation in serum hepatospecific markers such as aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and bilirubin and the levels of lipid peroxidation markers (thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides) in rat liver. Oxytetracycline also causes a significant reduction in the activities of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione (GSH), vitamin C and vitamin E in rat liver. Oxytetracycline (200 mg/kg) combined with Naringenin (50 mg/kg b.w.t.) significantly decreases the activities of serum aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and the levels of bilirubin along with significant decrease in the levels of lipid peroxidation markers in the rat liver. [1] Oxytetracycline (200 mg/kg, oral for 15 days) produces hepatic damage as manifested by a significant increase in serum hepatic markers namely aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and increases plasma and hepatic lipid peroxidation indices (TBARS and hydroperoxide) in rats. Oxytetracycline significantly decreases the levels of enzymatic antioxidants namely superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). [2] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 90 mg/mL (195.47 mM), Sonication is recommended.
Ethanol : 10 mg/mL (21.72 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (7.17 mM), Sonication is recommended.
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| Keywords | tetracycline | synthesis | protein | Oxytetracycline | m-ribosomal | Inhibitor | inhibit | HSV-1 | HSV | Herpes simplex virus | Gram-positive | Gram-negative | EndogenousMetabolite | Endogenous Metabolite | Bacterial | Antibiotic | aminoacil-tRNA | 30S ribosome | 16S ribosome |
| Inhibitors Related | Sucrose | Neomycin sulfate | Aceglutamide | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Glycerol | Thymidine | Gluconate Calcium | Dimethyl sulfoxide | Sodium bicarbonate |
| Related Compound Libraries | Pesticide Compound Library | Bioactive Compound Library | Drug Repurposing Compound Library | Natural Product Library | Anti-Viral Compound Library | Microbial Natural Product Library | Inhibitor Library | FDA-Approved Drug Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max |
United States
