| Name | Oxytocin |
| Description | Oxytocin (Syntocinon) is a mammalian neuropituitary hormone, a pleiotropic hypothalamic peptide and ligand for the oxytocin receptor, which contributes to labor, lactation, and pro-social behavior. Oxytocin has the ability to stimulate mammary secretion of breast milk, promote contraction of uterine smooth muscle during labor, and facilitate mothering. |
| In vitro | METHODS: KGN, MA-10 and C18-4 cells were treated with Tris(2,4-di-tert-butylphenyl)phosphate (0.1-100 µM) for 48 h. Cell counts were measured by Hoechst 33342 stained.
RESULTS: Tris(2,4-di-tert-butylphenyl)phosphate was not cytotoxic to any of the 3 cell lines. [1] |
| In vivo | METHODS: To assay acute anti-inflammatory activity in vivo, Tris(2,4-di-tert-butylphenyl)phosphate (50-70 mg/kg, 0.1% sodium carboxymethyl cellulose in 1M phosphate buffer pH 7.2) was administered to a carrageenan-induced rat foot-plantar edema model.
RESULTS: Tris(2,4-di-tert-butylphenyl)phosphate at the doses of 50 mg/kg and 70 mg/kg showed significant anti-inflammatory activity in the carrageenan-induced foot-plantar edema model. Tris(2,4-di-tert-butylphenyl)phosphate significantly reduced the volume of raw paw edema. [2] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (99.29 mM), Sonication is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | Syntocinon | OxytocinReceptor | Oxytocin Receptor | Oxytocin | alpha-Hypophamine | a-Hypophamine |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Cyclic Peptide Library | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Natural Product Library | Natural Product Library for HTS | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
United States
