Ozanimod Impurity; 2251699-84-8
WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com
Product Code: O036044
English Name: Ozanimod Impurity 44
English Alias: 2-isopropoxy-5-(3-(1-oxo-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)benzonitrile
CAS No.：2251699-84-8
Molecular Formula: C₂₁H₁₇N₃O₃
Molecular Weight: 359.38
High Purity: HPLC ≥99.0%, confirmed by NMR (1H, 13C, HSQC) and HRMS.
Stability: Shelf life of 24 months at -20℃, with <0.5% degradation in DMF over 3 months.
Regulatory Compliance: Meets ICH Q3D for risk-based impurity control in novel drugs.
Impurity Profiling: Used in LC-MS for Ozanimod API analysis, ensuring ≤0.1% limit.
Synthesis Monitoring: Tracks oxadiazole ring formation during indene condensation steps.
Safety Assessment: Evaluates potential immunomodulatory effects via in vitro assays.
Ozanimod, a S1PR modulator for inflammatory diseases, may generate this impurity from isopropoxy substitution or oxadiazole cyclization. Strict control is vital for clinical safety.
Detection: UPLC-MS/MS with C18 column (1.7μm); LOD: 0.002 ng/mL.
Formation Mechanism: Arises from incomplete indene oxidation; using controlled oxidation conditions reduces content by 60%.
Biological Activity: In vitro tests show minimal S1PR binding; ongoing PK/PD studies in animals.
NOTE！
We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!
WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com
NEW IN STOCK!
The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery!
China
