| Name | p-Ethynylphenylalanine hydrochloride |
| Description | p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent, and specific inhibitor of TPH[1]. Its potential to selectively and reversibly inhibit serotonin biosynthesis may contribute to characterizing the role of serotonin in behavioral and physiological activities[1]. |
| In vitro | p-Ethynylphenylalanine hydrochloride was demonstrated to inhibit competitively and reversibly TPH in vitro (Ki = 32.6 +/- 6.2 microM vs. tryptophan)[1]. |
| In vivo | Administration of p-Ethynylphenylalanine hydrochloride (30 mg/kg) to rats produced a 95 +/- 5% decrease in TPH activity in brain homogenates and a concomitant decrease in serotonin and 5-hydroxyindole-3-acetic acid levels (85%) at 24 h after injection[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 12 mg/mL (53.17 mM), Sonication is recommended.
DMSO : 99 mg/mL (438.69 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (14.62 mM), Sonication is recommended.
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| Keywords | Tryptophan Hydroxylase | tryptophan | TPH | serotonin | p-Ethynylphenylalanine Hydrochloride | pEthynylphenylalanine hydrochloride | p-Ethynylphenylalanine | p Ethynylphenylalanine hydrochloride | Inhibitor | inhibit | hydroxylase | 5-HT | 5-HIAA |
| Inhibitors Related | Mildronate | Fusaric acid | Tetrahydropapaverine hydrochloride | Casein | pCPA methyl ester hydrochloride | Telotristat Etiprate | p-Fluoro-L-phenylalanine | 4-Chloro-L-phenylalanine | Ketoconazole | Cuprizone | Fenclonine | SU 10603 |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library |
United States
