| Name | PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt) |
| Description | Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells. It binds to PACAP receptors on SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 24.5, 106, and 105 nM, respectively) and inhibits cAMP accumulation induced by PACAP (1-38) (Kis = 457, 102, and 283 nM, respectively, in SH-SY5Y, SK-N-MC, and T47D cells). |
| In vivo | In vivo, in newborn pigs, PACAP (6-27) (10 μM) inhibits vasodilation of pial arterioles induced by PACAP (1-27) and PACAP (1-38) . It also inhibits PACAP (1-27)-stimulated increases in plasma insulin and glucagon levels and pancreatic venous blood flow in dogs when administered locally to the pancreas at a dose of 500 μg. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 1 mg/mL, Sonication is recommended.
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| Keywords | PACAP (627) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt) | PACAP (6 27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt) | PACAP |
| Inhibitors Related | PACAP 1-38 acetate | PACAP (1-38) | PAC1R antagonist 1 | PACAP-38 (16-38), human, mouse, rat | PACAP-38 (31-38), human, mouse, rat acetate | PACAP (1-27), human, ovine, rat acetate | PACAP (6-38), human, ovine, rat acetate | PACAP (6-38), human, ovine, rat | PACAP (6-38), human, ovine, rat TFA | PA-8 | PACAP (1-38), human, ovine, rat | PACAP (1-38), human, ovine, rat TFA |
United States
