| Name | Pachymic acid |
| Description | Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways. |
| Cell Research | The anti-proliferative ability of PA on lung cancer cells was assessed by MTT, colony formation and EdU proliferation assays; cell cycle changes were detected by flow cytometry; apoptosis was detected by annexin V/PI double staining and DNA laddering; and the expression of apoptosis-related proteins was analyzed by Western blotting [1]. |
| In vitro | Porinic acid (PA) exerted antitumor effects on NCI-H23 and NCI-H460 lung cancer cells in vitro, while inducing cellular G2/M phase arrest and apoptosis. Our data showed that PA induced reactive oxygen species (ROS) production, leading to activation of c-Jun N-terminal kinase (JNK) and endoplasmic reticulum (ER) stress apoptotic pathways in lung cancer cells. Furthermore, blocking ROS production reversed PA-induced JNK and ER stress activation. Finally, PA inhibited the growth of NCI-H23 xenograft tumors without causing any toxicity to the host, and suppressed cell proliferation and induced apoptosis in tumor xenograft tissues [1]. At the same time, PA induced cell cycle arrest at G0 phase.PA also significantly inhibited cancer cell migration and invasion in a dose-dependent manner. Interestingly, PA inhibited the adhesion ability of cancer cells in a dose-dependent manner, which may contribute to the inhibition of cell invasion. Finally, it was shown that PA inhibited AKT and ERK signaling pathways. And tumor proteins such as PCNA, ICAM-1 and RhoA, which are involved in tumorigenesis, were also down-regulated by PA [1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 9.52 mg/mL (18 mM), Sonication is recommended.
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| Keywords | Protein kinase B | PKB | Pachymic acid | Inhibitor | inhibit | Extracellular signal regulated kinases | ERK | Akt |
| Inhibitors Related | Aceglutamide | Musk ketone | Stearamide | Urea | Bisphenol A | Gum arabic | Hyaluronic acid | Lactose | Ethyl linoleate | Methyl eugenol | Gluconate Calcium | 2,3-Butanediol |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Terpene Natural Product Library | Traditional Chinese Medicine Monomer Library | Pain-Related Compound Library | Kinase Inhibitor Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library |
United States
